Long-Term Sequelae of severe COVID-19: Outpatient assessment of radiological and pulmonary function tests

Objective: Identify lung sequelae of COVID-19 through radiological and pulmonary function assessment. Design(s): Prospective, longitudinal, cohort study from March 2020 to March 2021. Setting(s): Intensive Care Units (ICU) in a tertiary hospital in Portugal. Patient(s): 254 patients with COVID-19 admitted to ICU due to respiratory illness. Intervention(s): A chest computed tomography (CT) scan and pulmonary function tests (PFT) were performed at 3 to 6 months. Main variables of interest: CT-scan;PFT;decreased diffusion capacity of carbon monoxide (DLCO). Result(s): All CT scans revealed improvement in the follow-up, with 72% of patients still showing abnormalities, 58% with ground glass opacities and 62% with evidence of fibrosis. PFT had abnormalities in 94 patients (46%): thirteen patients (7%) had an obstructive pattern, 35 (18%) had a restrictive pattern, and 58 (30%) had decreased DLCO. There was a statistically significant association between abnormalities in the follow-up CT scan and older age, more extended hospital and ICU stay, higher SAPS II and APACHE scores and invasive ventilation. Mechanical ventilation, especially with no lung protective parameters, was associated with abnormalities in PFT. Multivariate regression showed more abnormalities in lung function with more extended ICU hospitalization, chronic obstructive pulmonary disease (COPD), chronic kidney disease, invasive mechanical ventilation, and ventilation with higher plateau pressure, and more abnormalities in CT-scan with older age, more extended ICU stay, organ solid transplants and ventilation with higher positive end-expiratory pressure (PEEP). Conclusion(s): Most patients with severe COVID-19 still exhibit abnormalities in CT scans or lung function tests three to six months after discharge.Copyright © 2023

Influence of Deep Sedation in Intensive Care Medicine Memories of Critical COVID-19 Survivors.

Introduction: Critical care survivors sustain a variety of sequelae after intensive care medicine (ICM) admission, and the Coronavirus Disease 2019 (COVID-19) pandemic has added further challenges. Specifically, ICM memories play a significant role, and delusional memories are associated with poor outcomes post-discharge including a delayed return to work and sleep problems. Deep sedation has been associated with a greater risk of perceiving delusional memories, bringing a move toward lighter sedation. However, there are limited reports on post-ICM memories in COVID-19, and influence of deep sedation has not been fully defined. Therefore, we aimed to evaluate ICM-memory recall in COVID-19 survivors and their relation with deep sedation. Materials/Methods: Adult COVID-19 ICM survivors admitted to a Portuguese University Hospital between October 2020 and April 2021 (second/third "waves") were evaluated 1 to 2 months post-discharge using "ICU Memory Tool," to assess real, emotional, and delusional memories. Results: The study included 132 patients (67% male; median age = 62 years, Acute Physiology and Chronic Health Evaluation [APACHE]-II = 15, Simplified Acute Physiology Score [SAPS]-II = 35, ICM stay = 9 days). Approximately 42% received deep sedation (median duration = 19 days). Most participants reported real (87%) and emotional (77%) recalls, with lesser delusional memories (36.4%). Deeply sedated patients reported significantly fewer real memories (78.6% vs 93.4%, P = .012) and increased delusional memories (60.7% vs 18.4%, P < .001), with no difference in emotional memories (75% vs 80.4%, P = .468). In multivariate analysis, deep sedation had a significant, independent association with delusional memories, increasing their likelihood by a factor of approximately 6 (OR = 6.274; 95% confidence interval = 1.165-33.773, P = .032), without influencing real (P = .545) or emotional (P = .133) memories. Conclusions: This study contributes to a better understanding of the potential adverse effects of deep sedation on ICM memories in critical COVID-19 survivors, indicating a significant, independent association with the incidence of delusional recalls. Although further studies are needed to support these findings, they suggest that strategies targeted to minimize sedation should be favored, aiming to improve long-term recovery.

Anxiety symptoms in critically ill COVID-19 survivors and its association with post-discharge health concerns

Introduction: Evidence suggest that critically ill COVID-19 patients are at higher risk of developing anxiety symptoms, which may be related to or exacerbated by patients concerns regarding their health status and recovery. Objective(s): To assess anxiety symptoms in critically ill COVID-19 survivors, 1-2 months after hospital discharge and to analyze its association with concerns reported by patients regarding their own health status and recovery. Method(s): In the framework of MAPA prospective research, this preliminary study included COVID-19 patients admitted in the Intensive Care Medicine Department (ICMD) of a University Hospital. Patients were excluded if they had an ICMD length of stay (LoS) <=24h, terminal illness, major auditory impairment or inability to communicate at the evaluation time. Participants were assessed at a scheduled telephone follow-up appointment, with Generalized Anxiety Disorder Scale (GAD-7). Additional questions were asked to assess the survivors' post-discharge concerns regarding discrimination against for COVID-19, infection of a family member, re-infection or sequelae related to COVID-19. Result(s): Eighty-three patients were included (median age=63 years;63% male) and 24% had anxiety symptoms. Anxiety scores were higher in survivors who reported being afraid of being discriminated against for COVID-19 (30% vs 10%;p=0.034), being re-infected (100% vs 79%;p=0.032) and having sequelae (94% vs 44%;p<0.001). Conclusion(s): These findings revealed that anxiety is common in COVID-19 survivors and is associated with post-discharge patients concerns that may limit patient daily living. This study emphasizes the importance of psychological assessment and follow-up of the COVID-19 survivors, in order to support these patients recovery.

Depression and health-related quality of life in critical COVID-19 survivors

Introduction: Long-term neuropsychiatric consequences of critical illness are well known. Therefore, it is expected that critical COVID-19 patients might also present several psychiatric symptoms such as depression, with inevitable negative effect on healthrelated quality of life (HRQoL), commonly used as an indicator of illness and treatment impact. Objective(s): To identify depressive symptoms in critical COVID-19 survivors and to examine its association with HRQoL domains. Method(s): This preliminary study involved critical COVID-19 patients admitted into the Intensive Care Medicine Department (ICMD) of a University Hospital, between October and December of 2020. Patients with an ICMD length of stay (LoS)<=24h, terminal illness, major auditory loss, or inability to communicate at the follow-up time were excluded. From 1-2 months after discharge, all participants were evaluated by telephone at follow-up appointment, with Patient Health Questionnaire (PHQ-9) (depression) and EuroQol 5-dimension 5-level EQ-5D-5L (HRQoL). This study is part of the longitudinal MAPA project. Result(s): Eighty-three patients were included with a median age of 63 years (range: 31-86) and the majority were male (63%). The most reported problems on EQ-5D-5L domains were usual activities (82%) and mobility (76%). About 27% presented depressive symptoms, and with more problems of self-care (68%vs41%;p=0.029), pain/discomfort (86%vs49%;p=0.002), and anxiety/depression (96%vs54%;p<0.001). Conclusion(s): These preliminary results are in line in previous studies in critical COVID-19 survivors, with depression being associated with worse HRQoL. Bearing this in mind, follow-up approaches with an early screening and treatment of these psychiatric symptoms will be fundamental to optimize the recovery of these patients.

Delirium and health-related quality of life in severe COVID-19 survivors

Introduction: Severe COVID-19 survivors experience long-term neuropsychiatric morbidity, particularly those who developed delirium, with a negative impact on health-related quality of life (HRQoL). Objective(s): To identify the cases of delirium in severe COVID-19 patients and to describe its association with post-hospital discharge HRQoL. Method(s): In the context of the longitudinal MAPA project, we included adult patients (>= 18 years old) admitted with COVID-19 to the Intensive Care Medicine Department (ICMD) of a Portuguese University Hospital (October 2020-April 2021). Exclusion criteria were: ICMD length of stay <=24h, terminal illness, major auditory loss, or inability to communicate at the time of assessment. Delirium during ICMD stay was ascertained based on patients' clinical records. HRQoL was evaluated using the 5-Level EQ-5D questionnaire (EQ-5D-5L), at a scheduled telephone follow-up appointment on average 1-2 months after hospital discharge. Result(s): Overall, 124 patients were included with a median age of 62 (range: 24-86) years, being mostly male (65%). About 19% had delirium, 42% were deeply sedated and 43% required invasive mechanical ventilation. Most survivors reported problems on the EQ-5D-5L domains: usual activities (85%), mobility (73%) and anxiety/depression (65%). Patients with delirium reported more pain/discomfort (75%vs46%;p=0.011) and considerably anxiety/ depression (83%vs60%;p=0.032). Conclusion(s): These findings pointed that COVID-19 patients who experienced delirium reported worse HRQoL, regarding pain/discomfort and anxiety/depression. This study highlights the importance of not only prevention but also early screening of delirium during hospital stay, as well as the crucial role of the timely interventions at discharge, in order to minimize delirium longterm impacts.

Depressive symptoms and health-related quality of life in critical COVID-19 survivors: Preliminary results of 1-year follow-up

Introduction: A higher risk of mental health consequences in critical COVID-19 patients is expected due to several reasons, including prolonged mechanical ventilation with exposure to high sedation. In this context, post-discharge depression has been reported in previous COVID-19 studies, with a profound impact on patients' health-related quality of life (HRQoL). Objective(s): To identify depressive symptoms in COVID-19 survivors 1-year after hospital discharge and to analyse its association with HRQoL. Method(s): As part of the longitudinal MAPA project, this study enrolled critical COVID-19 patients admitted in the Intensive Care Medicine Department of a University Hospital (March-May 2020). Participants were assessed through telephone by an intensive care nurse and a psychologist, with the Patient Health Questionnaire (PHQ-9) (depressive symptoms), EuroQol five-dimension fivelevel questionnaire (EQ-5D-5L) and EQ-Visual Analogue Scale (EQ-VAS) (global health status patient record). Result(s): A sample of 55 survivors (median age=66 years;69% males) were included, with 20% showing depressive symptoms. Pain/discomfort (67%) and anxiety/depression (67%) were the most EQ-5D-5L domains reported. Survivors scoring for depression had more problems in all HRQoL areas (mobility:91%vs.48%, p=0.015;self-care:64%vs.27%, p=0.035;usual activities:91%vs.50%, p=0.017;pain/discomfort:100%vs.59%, p=0.010;anxiety/depression:100% vs.59%, p=0.010). Moreover, they had a lower EQ-VAS median, corresponding a worse self-perception of health status (50vs.80, p=0.010). Conclusion(s): Even after 1-year, a significant proportion of survivors presented depressive symptoms with repercussions in all HRQoL dimensions and association with worse self-perception of global quality of life. Taking this in mind, early screening and treatment of depression in COVID-19 survivors will be crucial, minimizing its impact on quality of life.

“Tem hora pra tudo”: The reframing adverstising of VIVO in “Conexão” to the isolation market

The pandemic of the new coronavirus has (re)configured several projects of saying, in the varied spheres of discursive communication. In advertising, the responses elicited were quick. An example is the utterance “Conexão” (2020), which belongs to VIVO's campaign “Tem hora pra tudo” (2018/2020), which is the corpus of the analysis. In order to interpret this advertising film in its concrete and living enunciative unit, understanding its meanings/values/positions, we resort to Bakhtinian theoretical-methodological propositions, above all to the notions of chronotope, ideological sign and utterance. Through the analysis, we found that the brand's enunciative choices resignify its campaign for the “connection” (virtual) as social value and merchandise. © 2022 Thesaurus Editora de Brasilia Ltda.. All rights reserved.

Combined Acl and Anterolateral Ligament Reconstruction Confers Significantly Improved Long Term Outcomes When Compared to Isolated Acl Reconstruction: A Matched-Pair Analysis

Patients who undergo combined ACL and anterolateral ligament reconstruction experience significantly better long-term ACL graft survivorship, a five-fold lower risk of graft rupture, lower overall rates of re-operation, and no increase in complications when compared to those who undergo isolated ACL reconstruction Data Introduction Recent clinical studies have demonstrated significant advantages of combined anterior cruciate ligament and anterolateral ligament reconstruction (ACL+ALLR) over isolated ACL reconstruction (ACLR) with respect to reduced graft rupture rates, a lower risk of re-operation for secondary meniscectomy, improved knee stability, and higher rates of return to pre-injury levels of sport. However, due to the relative infancy of this procedure, long term studies have not yet been published, and it remains to be seen whether the reported advantages of the combined procedure are maintained at long term follow-up. The primary objective of this study was to compare the long-term clinical outcomes of isolated ACLR versus combined ACL+ALLR. The hypothesis was that patients who underwent combined procedures would experience significantly lower ACL graft rupture rates at long term follow-up than their matched counterparts who underwent isolated ACLR. Methods Patients undergoing primary ACL+ALLR between January 2011 and March 2012 were propensity matched in a 1:1 ratio to patients who had undergone isolated ACL reconstruction during the same period. Face-to-face post-operative follow-up was undertaken at 3 and 6 weeks, and 3, 6, 12 and 24 months. Due to the geographically mobile nature of young populations (particularly notable at long-term follow up), and the impact of COVID-19, the final follow up was conducted using a standardized telemedicine interview (between April and May 2020), completion of PROMs questionnaires and review of medical notes. The telemedicine interview and notes review sought to determine whether patients had sustained a further ipsilateral knee injury, had experienced any symptoms of knee instability or stiffness, or had undergone any re-operations or complications. As a result of these follow-up arrangements, physical examination findings (range of motion and knee stability) are reported at two-years follow up. Complications, re-operations and outcome measures including Lysholm, Tegner, IKDC and KOOS are reported at the final follow-up. Graft survivorship was assessed using Kaplan-Meier analysis. Logistic regression was performed in order to account for the potential impact of activity level on graft rupture rates. Results 86 matched pairs were included in the study. The mean duration of follow-up was 104.33+/-3.84 months (range 97-111 months). Patients who underwent combined ACL +ALLR experienced significantly better ACL graft survivorship (96.5% vs 82.6%, p=0.0027), lower overall rates of re-operation (15.3% vs 32.6%, p<0.05), lower rates of revision ACLR (3.5% vs 17.4%, p<0.05), and no increase in complications, when compared to those who underwent isolated ACLR. Patients undergoing isolated ACLR were at more than five-fold greater risk of graft rupture (OR, 5.549;95%CI 1.431 to 21.511, p = 0.0132), regardless of their pre-injury activity level. Conclusion Patients who undergo combined ACL and anterolateral ligament reconstruction experience significantly better long-term ACL graft survivorship, lower overall rates of reoperation, and no increase in complications when compared to those who undergo isolated ACLR. In contrast, patients undergoing isolated ACLR had a greater than five-fold increased risk of undergoing revision surgery at a mean follow- up of 104.3 months.

Positive Development Through Sport: Effects of the COVID-19 Pandemic and Future Challenges

Over the last few decades research has shown the potentiality of sports practice and of relationships experienced in this context to social and emotional skills development in different age groups. Theoretical models were proposed to support sports programs that aim to promote positive outcomes and adaptive behaviors that act as protective factors for mental health, contributing to a healthy development. However, physical distancing measures imposed by the COVID-19 pandemic prevented sport practices in the conventional way, as predicted in these models. The aim of this chapter was to discuss the impact of the COVID- 19 pandemic on the potentiality of sport to foster positive development in practitioners of different age groups, as well as to reflect on the challenges to be faced after the pandemic is controlled, specially those related to the resumption of in-person sports practices. In this sense, positive youth, adults and older adults development models in sports are presented, their main limitations in face of the pandemic, as well as possible theoretical and practical adaptations in sports programs to confront current and future challenges to the maintenance of sports practices. © 2021 by Nova Science Publishers, Inc.

PERFIL EPIDEMIOLÓGICOS DOS PACIENTES ENCAMINHADOS PARA O LABORATÓRIO DE REFERÊNCIA DO GRUPO GSH NO ANO 2020

Introdução: O aumento crescente da complexidade de casos relacionados a hemoterapia e avanços tecnológicos nos diagnósticos das doenças onco-hematológicas, associado ao aumento da expectativa de vida desta população, tem permitido que pacientes cada vez mais complexos sejam encaminhadas as especialidades médicas para definir o melhor tratamento a ser realizado. Objetivo: Realizar um levantamento do perfil epidemiológico das amostras de pacientes encaminhados para o laboratório de referência em imuno-hematológica para identificação de anticorpos irregulares devido transfusões ou sensibilizações. Materais e métodos: Levantamento estatístico utilizando o banco de dados do sistema informatizado do Banco de Sangue de São Paulo grupo gestor em hemoterapia. Resultados: 1.023 amostras de pacientes foram contabilizadas neste período do ano 2020, dos 1.023 pacientes 638 amostras eram do sexo feminino, e 385 amostras do sexo masculino. Quanto a idade recebemos amostras de pacientes com 1 dia de vida até 102 anos, de 0–10 (3,2%);0–20 (2,8%);21–30 (6,8%);31–40 (18,8%);41–50 (14,1%);51–60 (10,6%);61–70 (14,0%);71–80 (13,9%);81–90 (13,4%);91–102 (2,6%). Dentre as doenças relacionas estão aborto 45 (4,4%);Anemia hemolítica auto imune (IHAI) 6 (0,6%);Anemia sem especificação 105 (10,3%);Anemia Falciforme 36 (3,5%);COVID-19 53 (5,2%);Insuficiência Renal Crônica (IRC) 25 (2,4%);Leucemia sem especificação 87 (8,5%);Linfoma 55 (5,4%);Lúpus 5 (0,4%);Mielodisplasia 33 (3,2%);Mieloma Múltiplo 61 (6,0%);Neoplasia 16 (1,6%);Trombose 12 (1,2%);Transplante de Medula 11 (1,1%);Talassemia 16 (1,6%);Sepse 16 (1,6%);Sangramento 16 (1,6%);Parto 39 (3,8%). Nas identificações de anticorpos irregulares encontramos os seguintes anticorpos: D (162 – 15,8%);c (15 – 1,4%);C (8 – 0,8%);e (1 – 0,09%);E (75 – 7,3%);K (40 – 3,9%);Kpa (4 – 0,4%);Dia (28 – 2,7%);Fya (14 – 1,4%);Jka (10 – 1,0%);Jkb (4 – 0,4%);P1 (1 – 0,09%);S (3 – 0,3%);s (3 – 0,3%);M (27 – 2,3);N (2 – 0,2%);Lea (9 – 0,9%);Leb (1 – 0,09%);Lua (1 – 0,09%);Lub (1 – 0,09%);Fenotipagem estendida (276 – 27%);tipagem ABO direta/reversa (26 – 2,5%);TAD+/Auto+ (209 – 20,43%);Ausência de anticorpos (92 – 9,0%);auto e (3 – 0,3%. Crio aglutinina fria (12 – 1,2%). Conclusão: A maioria das amostras dos pacientes encaminhados ao laboratório de referência em imuno-hematologia para realizar os estudos imuno-hematógicos foram do sexo feminino, na faixa etária de 31–40 anos, as doenças com maior incidência foram leucemia, mieloma múltiplo, linfoma e COVID-19. Em relação aos anticorpos identificados o de maior prevalência foi D 15,8%. Esses resultados nos ajudam no planejamento e cuidado transfusional para esses pacientes.

P.0811 Factors and outcomes associated with delirium in critically ill COVID-19 patients

Introduction: Evidence demonstrates that 25-33% of hospitalized patients with COVID-19 develop delirium [1,2], with rates up to 65% in critically ill patients [3]. Several potential reasons, including the use of deep sedation and invasive mechanical ventilation (IMV), as well as the restrictions to limit infection transmission, such as prohibition of family visits and minimal contact with health staff were identified [4]. Although factors and outcomes associated with delirium are well documented, limited data are available regarding severe COVID-19 patients. Aims: This study aims to estimate the rates of delirium in critically ill COVID-19 patients and to analyze factors that may be associated with its development, as well as to examine long-term outcomes. Methods: From March to May 2020 (in COVID-19 first wave), all adult patients (≥18y.o.) admitted due to COVID-19, in the Intensive Care Medicine Department (ICMD) of a University Hospital (CHUSJ), in Porto, Portugal, were assessed, unless they had a ICMD length of stay (LoS) ≤24h, terminal illness or major sensory loss or inability to communicate at the time of follow-up. Participants were evaluated during a scheduled telephone follow-up appointment with a comprehensive protocol, including: Six-item Cognitive Impairment Test (6CIT) (cognitive impairment);Patient Health Questionnaire (PHQ-9) (symptoms of depression);General Anxiety Disorder (GAD-7) (symptoms of anxiety);and EuroQol five-dimension five-level questionnaire (EQ-5D-5L) (health-related quality of life-HRQoL), which includes EQ-Visual Analogue Scale (EQ-VAS) (global health status patient perception). Data on acute illness severity, sedative/analgesic drugs use, respiratory support and major complications (including delirium, nosocomial infections and difficulty weaning from mechanical ventilation) during ICMD stay, were obtained from hospital electronic records review. Patients with and without delirium were compared, using Mann-Whitney test for continuous variables, and Chi-square or Fisher tests for paired categorical variables (significance level of 0.05). This study is part of an ongoing larger multidisciplinary research project (MAPA-Mental Health in Critically ill patients with COVID-19). Results: The sample included 59 patients (median age=65 years;66.1% male). Delirium was registered in almost half of the sample (49.2%). Patients with delirium were significantly older (median=72 vs. 62;p=0.010) and presented more nosocomial infections (82.8% vs 53.3%;p=0.032) particularly ventilator-associated pneumonia (75.9% vs. 33.3%;p=0.003). Also, they were significantly more likely to be deeply sedated (89.7% vs 60%;p=0.021), more often required IMV (89.7% vs 60%;p=0.021). Moreover, those with delirium stayed longer in the hospital (median=67 vs 37 days;p=0.014). Concerning HRQoL, assessed at follow-up appointment, patients who have developed delirium reported more problems in self-care (48.3% vs 10%;p=0.003) and in everyday activities (79.3% vs 53.3%;p=0.035) after hospital discharge. Nevertheless, no statistically significant differences were found for cognitive impairment, symptoms of anxiety and depression. Conclusions: Delirium was common in this critically ill COVID-19 sample, namely in older patients, who have been deeply sedated, invasively ventilated or had major ICU complications. It was associated with longer hospital stay and worse HRQoL. Recognizing potential associated factors will allow the identification of high-risk patients that should be targeted for early screening with preventive interventions to minimize the adverse outcomes associated to delirium in critical COVID-19 patients. No conflict of interest

Post-discharge depressive symptoms and health-related quality of life of critical COVID-19 survivors

IntroductionSurvivors of critical illness stay frequently experience long-term mental health morbidity, suggesting that many critically ill patients with COVID-19 may also show a high prevalence of psychiatric conditions.ObjectivesTo describe depression in COVID-19 survivors 4-months post-hospital discharge and to examine its association with health-related quality of life (HRQoL).MethodsThis pilot study involved COVID-19 adult patients admitted in Intensive Care Medicine Service (ICMS) of a University Hospital. Exclusion criteria were: ICMS length of stay (LoS)≤24h, terminal illness, major sensory loss and inability to communicate at the time of assessment. All participants were evaluated at ICMS scheduled telephone follow-up appointment, with Patient Health Questionnaire (PHQ-9) (depression) and EQ-5D-5L (HRQoL). Critical-illness severity was assessed with APACHE-II and SAPS-II.ResultsTwenty patients were included with a median age of 62(range: 24-77) y.o., the majority male (75%) and married (70%). Median (range) APACHE-II and SAPS-II was 17 (5-34) and 32.5 (7-77), respectively, and LoS was 18 (4-58) days. Overall, 25% patients presented depression symptoms and most reported problems on EQ-5D-5L domains of pain/discomfort (65%), anxiety/depression (55%) and mobility (50%). Depression scores were higher in patients with problems in EQ-5D-5L domains of usual activities (median 4 vs 1.5;p=0.046), pain/discomfort (median 0 vs 4;p=0.004) and anxiety/depression (median 4 vs 0;p<0.001).ConclusionsThese preliminary findings show that depression is frequent in COVID-19 survivors and it is associated with worse HRQoL. This pilot study highlights the importance of psychological assessment and treatment of COVID-19 survivors, in order to minimize its negative impact on HRQoL, optimizing their recovery.

Clinical manifestations of covid-19 in children and adolescents: Systematic review

Objective: Analyze the occurrence of signs and symptoms of COVID-19 in patients up to 18 years of age. Data sources: A systematic review was carried out. Information was collected from the PubMed and ACM Digital Library databases, using descriptors (in English and Portuguese) such as children, adolescents, COVID-19, signs and symptoms. Search filters were applied: articles published within 7 months prior to the search date, descriptors present only in the title or abstract. Data synthesis: According to the articles studied, asymptomatology is notorious in children and adolescents. Regarding the clinical manifestations, caused by the SARS-CoV-2 infection, in pediatrics there is a predominance of fever, headache and fatigue (non-specific symptoms);cough, rhinorrhea, nasal congestion and odynophagia (respiratory symptoms);diarrhea and vomiting (gastrointestinal symptoms). There are also reports of other symptoms and dermatological manifestations. Conclusion: It is evident that, as it is recent, there is still little information about the clinical manifestations of COVID-19, especially in pediatrics, in which there is still a limited number of studies. However, it was possible to notice that most children and adolescents are asymptomatic and the most recurrent manifestations are fever and cough. © 2020, Nucleo de Estudos da Saude do Adolescente. All rights reserved.

Impact of COVID-19 on Oral Healthcare for Oncopediatric Patients: The Setting in a Reference Hospital in Northeast Brazil

Objective: To describe the impact of the COVID-19 pandemic on dental care provided to pediatric cancer patients assisted in a referral hospital. Material and Methods: This is an observational, retrospective study based on secondary data extracted from worksheets of dental procedures for patients aged between 0 and 19 years assisted in the pediatric oncology sector of a hospital in João Pessoa, PB, Brazil. Dental procedures performed by the interdisciplinary team of researchers from August 2018 to February 2020 (19 months prior to the pandemic) and from April 2020 to October 2021 (19 months during the pandemic) were totaled and compared. A descriptive analysis of the data was performed. Results: There was a reduction of 80.2% in dental interventions implemented in the sector during the pandemic, with the number of procedures decreasing from 6,210 (the period before the pandemic) to 1,229 (during the pandemic). Most procedures in both periods were performed for patients assisted in beds, for whom there was a reduction of care provided for 81.2% from 5,275 to 994 procedures. Dental procedures in the outpatient clinic decreased by 74.9%, from 935 to 235. Conclusion: The COVID-19 pandemic negatively impacted dental care provided to pediatric oncology patients by restricting dental procedures to emergency demands, compromising performance prevention and health promotion actions.